John 3:16 (NIV)
16 “For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.

3:16 Muslims claim that God could not have a Son because they think Christians are talking about a literal biological offspring of the Father and Mary. However, throughout the NT, and especially in John, sonship refers to the intimate spiritual relationship between God and JesusThe Apologetics Study Bible: Understanding Why You Believe.